Endocrine Abstracts

Introduction: Primary hyperparathyroidism causes accelerated bone turnover and the consensus is to measure and act upon the 25hydroxyvitamin D level in order to reduce the drive to PTH production, slow down BMD loss, and prevent hungry bone syndrome. How best to replace vitamin D is less clear so we chose to audit our current practice.Method: In 12 months 120 patients with primary hyperparathyroidism were identified retrospectively, 98 of which were vita...

Introduction: Glycogen storage disease type 1a (GSD1a) is an inborn error of metabolism with several metabolic decompensations including anaerobic glycolysis and lactic acidosis but few known about GSD1a-related hypercalcemia. Here we aimed to present a putative relationship between serum Ca and the affected metabolic parameters during metabolic decompensation of GSD1a.Case report: Two patients with GSD1a and hypercalcemia were retrospectively analyzed. ...

Objective: Diabetes mellitus (DM) is a complex disease that affects many systems. The most important cells of the immune system are lymphomononuclear (LMN) cells. Here, we aimed to evaluate the energy metabolism of LMN cells in patients with diabetes and impaired glucose tolerance.Methods: We measured LMN cell energy metabolism in patients with type 2 diabetes mellitus, impaired glucose tolerance (IGT) and healthy subjects. Cells were freshly isolated fr...

Aims: To define and identify patients who have ‘failed’ parathyroidectomy by a single surgeon. To explore common features of these cases to refine our pathways.Methods: This case note review began with a retrospective audit of 123 patients having neck exploration from January 2009 to May 2014. The dataset of clinicopathological information obtained from the electronic Trust records, was interrogated to identify patients fulfilling the following...

Rhabdomyolysis is a syndrome characterized by muscle necrosis and the release of intracelluler muscle contents into systemic circulation. It can became a life-threatening disorder when complicated by acute tubuler necrosis and renal failure. Fenofibrate, a fibric acid derivate, is used to treat diabetic dyslipidemia, hypertriglyceridemia and combined hyperlipidemia alone or in combination with statins. Rhabdomyolysis associated with fenofibrate is extremely rare. In nearly all...

Graves’ disease (GD) is an autoimmune and polygenic disorder. The genetic loci conferring susceptibility need to be still defined. Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene has been reported to be associated with GD in various ethnic groups. The aim of the present study was to determine whether CTLA-4 gene was associated with GD in Turkish population. We evaluated the allele distribution of the following loci: CTLA-4 exon 1 (+49 A/G) and promoter (−318 C/T) reg...

Hyperinsulinism has been shown to trigger sympathetic activity experimentally, however the clinical and epidemiologic data on the association of heart rate with hyperinsulinism and insulin resistance. This study was investigated the relationship between insulin resistance and exercise test parameters in unselected consecutive middle aged asymptomatic patients with type II diabetes.Ninety asymptomatic type II diabetics between the ages 36 and 60 without a...

Accelerated coronary and peripheral vascular atherosclerosis is one of the most common and chronic complications of diabetes mellitus. A relatively recently analysed aspect of coronary artery disease in this condition is its silent nature. We studied silent myocardial ischaemia (SMI) in unselected consecutive middle aged asymptomatic patients with type II diabetes by treadmill exercise test.Ninety four asymptomatic type II diabetics between the ages 36 a...

Background: Primary hyperparathyroidism (PHPT) is associated with various musculoskeletal complaints. It is difficult to evaluate muscle strength as it is hard to extract objective data due to lack of definite methods for measurement.Objective: To assess the differences between PHPT patients and healthy controls regarding maximum foot force and plantar pressure distribution by using platform pressure measuring system [Footscan (RSscan)].<p class="abs...

Background: Parathyroid Carcinoma (PC) is a very rare endocrine malignancy. Unlike Parathyroid Adenoma (PA) and Parathyroid Hyperplasia which represents 80% and 15-20% cases of primary hyperparathyroidism (PHPT) respectively, PC only constitutes 1-2% of cases. Herein we present a clinical case of PC following a low-impact trauma.Clinical case: A 50-year-old Bulgarian female presented with a pathological mid-shaft fracture of her right femur following a t...